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High viral load hiv transmission heterosexual - United States

   02.07.2018  1 Comments

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Terms of use and Your privacy. A new African study of heterosexual HIV-serodiscordant couples—in which one partner is positive and the other is negative—confirms that viral load is the most important factor influencing the risk of transmitting the virus, according to data published in the February 1 issue of The Journal of Infectious Diseases.

The findings also stress the importance of other transmission variables, including condom use, age, male circumcision status and the presence of other sexually transmitted infections STIs. According to study authors James Hughes, PhD, of the University of Washington and his colleagues, the average rate of infection was found to be 1 per coital acts.

Though estimates of the probability of HIV infection per act of sexual intercourse can be confusing on a level of personal decision making—it only takes one unsafe sexual encounter to become infected with the virus—these estimates are of importance to experts in the field of HIV epidemiology and prevention. The couples had frequent follow-up to measure viral loads in the positive partner; this included genetic testing to link the transmitted virus to the HIV-positive partner in order to prevent including infections acquired from other possible partners.

Overall, there were one to two incidents of HIV transmission per 1, acts of sexual intercourse—a rate similar to those found in other low-income countries, but higher than estimates from many industrialized countries. The viral load in the original infected partner was the main driver of transmission, with the risk increasing 2.

This finding was somewhat higher than previous estimates of transmission risk associated with viral load, possibly because the short follow-up intervals and frequent viral load measurements in the study allowed more precise estimates of the association between HIV levels and infectivity.

The study also confirmed that condoms are highly protective, reducing the risk of HIV transmission by 78 percent when volunteers self-reported condom use. Older age was also associated with reduced transmission per sex act, as has been previously reported, and male circumcision reduced female-to-male transmission by about 47 percent, an effect compatible with the efficacy reported in three randomized trials of circumcision for HIV prevention.

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- United States On average, each time a monogamous, heterosexual couple in which one partner is HIV-positive has intercourse, the probability that the virus will be transmitted to the uninfected partner is 0.

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Viral load determines how infectious bodily fluids are. Levels are highest in someone who is lately infected up to 40 million copies in a millilitre of blood.

When viral load is very high, normally low imperil activities like giving oral intimacy become a higher risk. The risk of transmission from shafting without a condom is dramatically reduced when an HIV complimentary person is on treatment. If viral load is undetectable that risk become zero. In beginning studies, the single transmissions occurred when the positive partner had only just started treatment when their viral load was silently high.

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